Variation of serum NSE and S-100 β in patients with acute cerebral infarction subtypes

AIM: To explore clinical significance of the serum changes of neuron-specific enolase (NSE)and S-100 β protein (S-100 β) during acute cerebral infarction. METHODS: 59 acute cerebral infarction patients were classified as total anterior circulation infarcts (TACI), partial anterior circulation infarcts (PACI), lacunar infarcts (LACI) and posterior circulation infarcts (POCI). Their serum NSE and S-100 β concentrations were determinated by enzyme linked immunosorbent assay (ELISA) during stroke onset 6 d, and compared with 32 controls. RESULTS: The every time point serum NSE concentration of TACI was higher than controls (P＜0.01), and its highest value occured at 3 d after the onset. The every time point concentration of PACI was also higher than controls (P＜0.05), its highest value occured at 1 d after the onset. The increment of serum S-100 β synchronized with serum NSE change in TACI. The S-100 β of PACI started to increase at 3 h after the onset, its highest value occured at 1 d after the onset, and concentration at 6 h, 1 d, 3 d and 6 d was markedly higher than controls (P＜0.05). However, the every time point NSE and S-100 β concentrations of LACI and POCI increased unmarkedly compared with control group. CONCLUSIONS: The serum NSE and S-100 β changes in acute period (contains acute early period) of cerebral infarction subtypes might be different. These results might help to treat acute cerebral infarction according to the classification.