Therapeutic effects of losartan and astragalus membranaceus on diabetic nephropathy |
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Authors: | FENG Lie FENG Yi LU Xiao-hua |
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Institution: | 1. Department of Endocrinology, First Affiliated Hospital of Jinan University, Guangzhou 510632, China;
2. Department of Endocrinology, People's Hospital ofZhongshan City, Zhongshan 528400, China |
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Abstract: | AIM: To observe the protective effects of losartan and astragalus membranace on the kidney of diabetic rats, and to study their possible mechanisms. METHODS: The diabetic rats were induced by a single intraperitoneal injection of streptozotocin. At the end of 12th week,changes in urinary albumin excretion, urinary β2-MG excretion, Ccr,NO,ET-1 levels in blood, urinary and renal tissue were observed. Serum and urinary TGF-β1 concentration,average volume of glomeruler,average thickness of glomerular basement membrane were also measured. RESULTS: In the treated diabetic rats, urinary albumin excretion, urinary β2-MG excretion, Ccr, urinary and renal tissue NO, urinary TGF-β1, average volume of glomeruler, average thickness of glomerular basement membrane decreased obviously as compared with diabetic untreated rats. These effects were enhanced when losartan was combined with astragalus membranace. CONCLUSION: Losartan or astragalus membranace reversed the injury of renal structure and function in STZ-induced diabetic rats. The protective effects were enhanced when losartan was combined with astragalus membranace. The decrease in NO,ET,TGF-β1 concentration in renal tissue may be one of mechanisms for this action. |
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Keywords: | Diabetic nephropathies Losartan Astragalus membranaceus Nitric oxide Endothelin-1 Transforming growth factor beta |
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