Recent advances in lectin-like oxidized low-density lipoprotein receptor-1 and atherosclerosis |
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Authors: | ZHU Hui-lian LING Wen-hua |
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Affiliation: | School of Public Health, Zhongshan University, Guangzhou 510080, China |
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Abstract: | Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a type-Ⅱ membrane protein belonging to the C-type lectin family molecules, which acts as a cell surface endocytosis receptor for atherogenic oxidized LDL (Ox-LDL). LOX-1 supports the binding internalization and proteolytic degradation of oxidized LDL, but not of significant amounts of acetylated LDL. LOX-1 is initially synthesized as a 40 kD precursor protein with N-linked high mannose-type carbohydrate, which is further glycosylated and processed into a 48-kD mature form. In vivo, endothelial cells that cover early therosclerotic lesions, intimal macrophages and smooth muscle cells in advanced atherosclerotic plaques express LOX-1. LOX-1 is cleaved at membrane proximal extracellular domain and released from the cell surface. Measurement of soluble LOX-1 in vivo may provide novel diagnostic strategy for the evaluation and prediction of atherosclerosis and vascular diseases. |
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Keywords: | Lectin-like oxidized low density lipoprotein receptor-1 Arteriosclerosis Oxidized LDL |
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