Association of F XⅢVal34Leu with coronary heart disease |
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| Authors: | FENG Bei-li XU Geng JIN Guo-dong SHI Yu-ping FU Guo-sheng MA Ji SHAN Jiang |
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| Institution: | Department of Cardiology, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China |
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| Abstract: | AIM: To investigate the distribution of coagulation factor XⅢ (FXⅢ) Val34Leu polymorphism in Chinese and the relationship between the polymorphism and coronary heart disease (CHD) or myocardial infarction. METHODS: A total of 195 patients with angiographically confirmed CHD and 203 controls were genotyped for the Val34Leu polymorphism by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis. RESULTS: The FXⅢ Val34Leu was found in 19 out of all 398 samples (4.8%) representing a Leu allele frequency of 2.4%. The distribution of FXⅢ genotype and allele was not significantly different between all patients and controls (P>0.05). The Val/Leu genotype and Leu allele frequencies in subjects without MI were significantly higher than that in subjects with MI (P<0.05). CONCLUSION: There is F XⅢ Val34Leu polymorphism in Han ethnic group. |
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| Keywords: | Coronary disease Factor XⅢa Polymorphism restriction fragment length Genes factor XⅢa Myocardial infarction |
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