Localization and expression of TGF-β1,2 in fetal and adult skins |
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Authors: | CHEN Wei FU Xiao-bing SUN Tong-zhu ZHAO Zhi-li ZHOU Gang SUN Peng YANG Yin-hui SHENG Zhi-yong |
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Affiliation: | Key Research Laboratory of Wound Repair, 304th Hospital of PLA, Beijing 100037, China |
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Abstract: | AIM:To explore the localization and expression of transforming growth factor-β1,2 (TGF-β1,2) and alpha-smooth muscle actin (α-ASMA) in fetal and adult skins. METHODS:Skins of 15 cases of fetuses with different gestational ages and 5 cases of adults were taken, embedded with paraffin wax, and sectioned. Immunohistochemistry method and pathological method were used to detect the expression intensity and distribution of TGF-β1,2 and α-ASMA. RESULTS: Positive immunohistochemical signals of TGF-β1, 2 and α-ASMA were found in fetal and adult skins. In skins derived from young fetus, the positive signals of these three proteins were very weak. Along with the increment in gestational age, the positive cellular rates of TGF-β1,2M and α-ASMA were elevated progressively. In elder fetal and adult skins, TGF-β1,2 were mostly distributed in epidermal cells, endothelial cells and some fibroblasts, while α-ASMA was mainly located in myofibroblasts and sweat gland epithelial cells. CONCLUSION:The endogenous TGF-β1,2might be involved in the cutaneous development at embryonic stage, in the cutaneous structure maintenance at adult stage, and in the wound healing after injury. |
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Keywords: | Transforming growth factor beta Alpha-smooth muscle actin Fetal skin Scarless healing |
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