Action of NF-κB p65 in renal interstitium in rats with active Heymann nephritis |
| |
Authors: | DU Xiao-gang GAN Hua XIAO Gang |
| |
Institution: | Department of Nephrology, The First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016, China |
| |
Abstract: | AIM: To study the action of NF-κB p65 in tubule-interstitium in rats with active Heymann nephritis(AHN). METHODS: Twenty female Wistar rats in 6-8 weeks of age were divided into two groups. The nephritis was induced with Fx1A/CFA by subcutaneous injection and with CFA as control. After rats were killed, the activation of NF-κB p65 in renal tissue was observed by immune histochemistry. RESULTS: The lesion score of renal interstitium and activation of NF-κB p65 of renal tubule in rats with AHN was higher than those of control group(P<0.01). A positive correlation was found between the positive rate of NF-κB p65 in renal tubule and the lesion score of renal interstitium, the levels of urinary protein (r=0.7138 and 0.6376, P<0.05).CONCLUSION: The activation of NF-κB p65 participates in the damage of pathophysiological functions of tubule-interstitium in AHN. |
| |
Keywords: | Nephritis Tubule-interstitium NF-kappa B |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|