Downregulation of aortic angiotensin II type 1 receptor mRNA expression by simvastatin in hyperlipidemic rats |
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Authors: | WU Jun WANG Lian-sheng CHEN Min-sheng SUN Ming ZHOU Hong-yan XU Hui ZHOU Hong-hao |
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Affiliation: | 1. Department of Cardiology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China;2. Clinical Pharmacology Research Institute of Central South University, Changsha 410078, China;3. Department of Cardiology, Xiangya Hospital of Central South University, Changsha 410008, China |
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Abstract: | AIM:To study the impact of hyperlipidemia on aortic AT1 mRNA expression and vasoactive substances, and investigate the potential mechanism on reversion of endothelial dysfunction during the statin therapy.METHODS:The investigation included control, hyperlipidemic and simvastatin-treated groups. Hyperlipidemic model was set up on the 4-week atherogenic diet, followed by a 16-week treatment in the simvastatin treated group (simvastatin 10 mg·kg-1·d-1) and without treatment in the hyperlipidemic group. Serum lipid level, the expression of AT1mRNA of aorta and level of serum AngⅡ and nitric oxide (NO) were measured. RESULTS: Compared with the control group, hyperlipidemic rats showed a stronger expression of AT1 mRNA and lower level of NO. No significant difference in systolic blood pressure and AngⅡ was showed in this group. In contrast, in simvastatin treated group, expression of AT1 mRNA as well as lipid(TC, TG, LDL-C) levels were significantly decreased and NO level increased which associated with improvement of endothelial dysfunction. CONCLUSION:By regulated the lipid level, downregulated AT1 mRNA expresstion and increased the NO activity, simvastatin restored endothelial function and inhibited atherogenesis. |
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Keywords: | Simvastatin Hyperlipidemia Receptors angiotensin Nitric oxide |
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