TGF-β-activated MAPK cascade and its regulation on cells |
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| Authors: | XUE Dong-ying HONG Jia-he |
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| Affiliation: | Institute of Liver Disease, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
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| Abstract: | Transforming growth factor-β(TGF-β)is a multifunctional growth factor.It plays a very important role in the growth, differentiation, migration, apoptosis of cells and production of extracellular matrix throughout many signaling pathways.MAPK cascade is one of those signaling pathways.TGF-βcan activate MAPKs and fulfill its multiple regulation on a variety of cells. |
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| Keywords: | Transforming growth factor beta Mitogen-activated protein kinases Signal transduction |
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