Effects of thymosin α1 on the development and maturation of thymocytes |
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| Authors: | ZHANG Ting WANG Shu-qiu SUN Yun-hui ZHANG Jian-hua XING Feng-you |
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| Institution: | 1. Department of Pathophysiology, Medical College, The First Affiliated Hospital, Jiamusi University, Jiamusi 154007, China;
2. Department of Respirology, The First Affiliated Hospital, Jiamusi University, Jiamusi 154007, China |
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| Abstract: | AIM: To investigate the effect of Thymosin α1 on the development and matutation of thymocytes. METHODS: The proportion of CD4+CD8+ thymocytes and the expression of smoothened (Smo) of the hedgehog (Hh)-signaling in CD4-CD8-thymocytes were examined to observe the effect of thymosin α1 on thymocyte development and matutation. RESULTS: Flowcytometric analysis showed that thymosin α1 showed activity at a low dose of 30 μg/kg, and 30 μg/kg thymosin α1 accelerated the replenishment and maturation of thymocytes according to the expression of Smo of the Hh-signaling in CD4-CD8-thymocytes, the potent negative regulator of proliferative responses. CONCLUSION: Thymosin α1 can accelerates thymocyte development from CD4-CD8- to CD4+CD8+. |
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| Keywords: | Thymosin Thymocytes Development |
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