Protective effect of cardiomyopeptidin on cultured rat neonatal myocardial cells damaged by adriamycin |
| |
| Authors: | LI Ru-bing FU Yong-hang WAN Hua-yin PAN Yun LI Ji-dong LI Shu LIANG Qiang KONG Xiang-ping |
| |
| Affiliation: | 1. Department of molecular Biology, the Infectious Disease Center, the 458th Hospital of PLA, Guangzhou 510602, China;2. Dalian Zhen'ao Pharmaceutical Limited Company, Dalian 116620, China |
| |
| Abstract: | AIM:To investigate the protective effect of cardiomyopeptidin on cultured myocardial cells damaged by adriamycin in neonatal rats.METHODS:The activities of CPK, LDH and the dehydrogenase of mitochondria in the cells damaged by adriamycin were observed in the presence or absence of cardiomyopeptidin, i was measured with fluorescent dye Fura-2-AM.RESULTS:Cardiomyopeptidin reduced the activities of CPK and LDH and increased the activities of dehydrogenase of mitochondria in a dose-dependent manner; CMP also dose-dependently decreased i.CONCLUSION:Cardiomyopeptidin has a protective effect on cultured rat neonatal myocardial cells damaged by adriamycin. |
| |
| Keywords: | Cardiomyopeptidin Doxorubicin Myocardium Calcium |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
|
点击此处可从《园艺学报》下载全文 |
|
