Inhibitory effects of LDL-ACM complex on subcutaneous implanted tumors in nude mice() |
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Authors: | JIANG An-li KANG Lu-dong ZHAO Chun-hua BI Wen-xiang HU Xiao-yan KONG Feng XU Song-de |
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Affiliation: | Department of Biochemistry, Medical College of Shandong University,Jinan 250012, China |
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Abstract: | AIM: In order to evaluate the applicable value of LDL as a targeted vehicle for chemotherapeutic agents, we investigated and compared the inhibitory effects of LDL-ACM complex and free ACM on nude mice's subcutaneous implanted tumors derived from gastric cancer cell lines, SGC-7901 and NKM-45. METHODS: LDL-ACM complex was prepared and the tumor model of nude mice was established by subcutaneous implantation of SGC-7901 and NKM-45. Then, the groups of nude mice developed subcutaneous implanted tumors were received either LDL-ACM complex or free ACM. Subsequently, the tumor size, weight and leukemia cell counts were measured and the rates of tumor-inhibition and the survival were compared among the groups. RESULTS: The inhibitory effects of LDL-ACM complex on the tumors, especially on SGC-7901 implanted tumors were much more obvious than that of free ACM. It was also indicated that the action of LDL-ACM complex was mediated by LDL receptor. CONCLUSION: These results showed that LDL-ACM complex had significant inhibitory effects on the implanted tumors and the effect might be mediated by LDL receptor. |
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Keywords: | Lipoproteins LDL Aclarubicin Mice nude Stomach neoplasms cell lines |
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