Characteristics of transient outward potassium current in repolarization 1 phase from the canine right ventricular mid-myocardial cells |
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Authors: | ZHOU Peng YANG Xin-chun LI Cui-lan LIU Xiu-lan GAO Ying WANG Li-zhong LUO Jing |
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Affiliation: | Cardiovascular Disease Institute Affiliated Capital University of Medical Sciences, Heart Center of Beijing Chaoyang Hospital, Beijing 100020, China |
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Abstract: | AIM: To examine the electrophysiological characteristics of transient outward potassium current(Ito1) in repolarization 1 phase from the canine right ventricular M cells. METHODS: By use of whole cell patch-clamp technique, we quantitatively researched the ionic intensity, density of Ito1 and the notch magnitude of action potential in repolarization 1 phase. RESULTS: (1) The activating process of Ito1 of canine right ventricular M cells presented evident voltage-dependency. Under the condition of 37℃, 5 000 ms, 0 mV and +70 mV, the average peak Ito1 intensity of right ventricular M cell were (690±380) pA and (3 130±1 910) pA, respectively (P<0.01). (2) The Ito1 intensity of canine right ventricular M cell possessed obvious frequent dependency. Under the condition of 37℃,+70 mV, 500 ms and 5 000 ms, the average peak Ito1 intensity were (1 690±830) pA,(3 130±1 910) pA, respectively(P<0.01), corresponding to the increase of action potential "spike-dome" magnitude in repolarization 1 phase. CONCLUSION: Potent Ito1 as well as the "spike-dome"-like action potential figure mediated by Ito1 is one of the prominent electrophysiological characteristics of the canine right ventricular M cells. |
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Keywords: | Electrophysiology Dogs Heart Potassium current |
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