APE/Ref-1 protein and ischemia/reperfusion injury of neurons in the brain |
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Authors: | WANG Xiao-song LI Zhi-wen |
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Affiliation: | Institute of Neurology, First Afiliated Hospital, Fujian Medical University, Fuzhou 350005, China |
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Abstract: | Cerebral ischemia and the aftermath of reperfusion form a hypoxic/hyperoxic sequence of events that can trigger DNA damage in neurons of central nervous system. Neuronal apoptosis will happen without immediate DNA repair. APE/Ref-1 is a multifunctional protein involoved in DNA base excision repair pathway and in redox reguiation of DNA-binding activity of AP-1 family members, which may play an important role in protection of postischemic neuronal damage. |
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Keywords: | APE/Ref-1 protein Brain ischemia Neurons DNA damage DNA repair |
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