Changes of serum prostate specific antigen content,volume of prostate,and serum testosterone content with aging

AIM: To study the relationship between serum prostate specific antigen (PSA) and sex hormones as well as PSA change with aging and volume of prostate. METHODS: Volume of prostate was measured by supersonic diagnostic set. Serum PSA content was determined by ELISA. Serum testosterone and Luteinizxing hormone (LH) contents were measured by radioimmunoassay. The relationship between volume of prostate, PSA , sex hormones and PSA with aging was analyzed. RESULTS: (1) Serum PSA increased with aging. (2) Declined serum levels of testosterone with aging were detected. Serum LH contents increased with aging. (3) PSA and LH contents were positively correlated with aging and volume of prostate. (4) The testosterone levels were negatively correlated with the volume of prostate (r=-0.45,P＜0.01). CONCLUSION: The amount of serum PSA is correlated with the histological changes of the benign hyperplasia of prostate, and the declined serum testosterone is one of the most important reasons of abnormal hyperplasia of prostate.