A comparative study on urinary complement C5b-9 complex excretion in four nephritis models of rats |
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| Authors: | WANG Ying-wei JIAN Jie TANG Ren-xian HUANGShui-ping |
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| Institution: | 1. Department of Immunology,Nanjing Medical University,Nanjing 210029,China;
2. Department of Immunology,Xuzhou Medical College,Xuzhou 221002,China;
3. Department of Statistics,Xuzhou Medical College,Xuzhou 221002,China |
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| Abstract: | AIM: To explore the significance of measuring urinary complement C5b-9 complex in various types of immune complex (IC) nephritis models of rats. METHODS: The four models of rats, namely, passive Heymann nephritis (PHN), anti-thymocyte serum nephritis(ATSN), anti-glomerular basement membrane nephritis (AGBMN) and chronic serum disease nephritis (CSDN) were reproduced. Then, the contents of complement C5b-9 complex in plasma and urine of the rats were detected with sandwich ELISA. And the deposits of C5b-9 complex in glomeruli of the rats were examined by ABC immunohistochemistry staining. CONCLUSION: Urinary C5b-9 complex excretion could be taken as one of several sensitive immunologic parameters in diagnosing of PHN and in distinguishing PHN from other type of nephritis. |
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| Keywords: | Nephritis Complement C5b-9 complex Rats |
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