Injury of hepatic mitochondria and its pathogenesis in rats with endotoxemia |
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| Authors: | BI Ming-hua ZHANG Shu-wen WANG Bao-en LIU Shu-sen SONG Wei |
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| Institution: | 1. Critical Care Department, Beijing Friendship Hospital, Beijing 100050, China;
2. China Institute of Zoology, Beijing 100050, China |
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| Abstract: | AIM:To investigate the effect of endotoxin on rat hepatic mitochondria.METHODS:Rats were randomly divided into two groups:endotoxin group and the control. 8 cases of animals were included in each group. The effect of electron leak on the production of endogenous oxygen free radicals and the changes of mitochondria function were studied.RESULTS:Treated with endotoxin, a significant increase in O2 and the rate of state 3,4 were observed in liver mitochondria; The rate of electron transfer to proton pump of mitochondria respiratory chain complex Ⅱ+Ⅲ(H+/2e-), respiratory control rate and ADP/O decreased significantly.CONCLUSION:A increase in production of endogenous oxygen free radicals induced by endotoxin plays an important role in the injury of rat liver mitochondria. |
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| Keywords: | Mitochondria liver Endotoxins Rats |
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