Role of endogenous angiotensin II in the pathogenesis of aortic calcification in rats |
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| Authors: | WU Sheng-ying PAN Chun-shui LIU Xiu-hua JIANG Wei QI Yong-fen TANG Chao-shu LI Ju-xiang |
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| Institution: | 1. Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China;
2. Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083, China |
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| Abstract: | AIM: To explore the effects of angiotensin II on aortic calcification in the rat. METHODS: Arterial calcification of Sprague-Dawley rats was induced by vitamin D3 plus nicotine. Calcification was confirmed by Von Kossa staining, measurement of calcium content, 45Ca2+]accumulation and alkaline phosphatase (ALP) activity of vascular tissue. RESULTS: The results showed that calcium content, 45Ca2+]accumulation and ALP activity in calcified arteries increased significantly compared with those of control. Ang Ⅱ levels in plasma and aortic tissues and the amount of angiotensinogen mRNA in calcified aorta were also increased as compared with control. Captopril (inhibitor of ACE) and losartan (Ang Ⅱ receptor inhibitor) decreased significantly the content of calcium, 45Ca2+] uptake and ALP activity in calcified aorta. Ang Ⅱ levels in plasma and aortic tissues and the amount of angiotensinogen mRNA in aortic tissue were down-regulated by captopril. The amount of angiotensinogen mRNA and the content of Ang Ⅱ in the calcified aorta were also decreased by losartan. CONCLUSION: The captopril and losartan significantly alleviate the vascular calcification. |
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| Keywords: | Angiotensin II Captopril Losartan Blood vessels Calcification |
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