Endocrine differentiation and its mechanism in endometrial carcinoma |
| |
| Authors: | LU Xiao-ye WANG Zi-neng HUANG Zhong-xin QIN Li |
| |
| Institution: | 1. Department of Histology and Embryology, Medical College of Jinan University, Guangzhou 510632, China;
2. Department of Gynaecology and Obstetrics, The First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, China |
| |
| Abstract: | AIM:To investigate endocrine differentiation and its mechanism in endometrial carcinoma.METHODS:Endocrine cells (EC) were identified by immunohistochemical staining of chromogranin A in 50 cases of endometrioid adenocarcinoma and 20 cases of normal endometrium. Double-label techniques were used for simultaneous demonstration of the CgA and cytokeratin.RESULTS:The positive rate of CgA in endometrioid adenocarcinoma was 44.0%, and was significant higher than that in normal endometrium (15.0%, P＜0.05). Scanty EC was present in normal endometrium. The number and staining intensity of EC in endometrioid adenocarcinoma were greater than that in normal. Co-expression of CgA and cytokeratin were detected in endometrioid adenocarcinoma.CONCLUSION:The presence of endocrine cells in endometrioid adenocarcinoma showed heterogeneity of tumors. The occurrence of "Multidirectional differentiation cells" within the endometrioid adenocarcinoma may indicate that endocrine cells derive from malignant cells of multidirectional differentiation. |
| |
| Keywords: | Endometrial neoplasms Neuroendocrine tumors Endocrine cells |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
