Expression and role of CD134 and NF-κB in renal tissue of lupus nephritis |
| |
Authors: | ZHOU Yan-bin YE Ren-gao XIE Can-mao XU Han-shi GUAN Wei-ming YANG Xiao YANG Nian-sheng |
| |
Affiliation: | 1. Department of Nephrology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;2. Respiratory Division, Department of Internal Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China |
| |
Abstract: | AIM:To investigate the role of CD134 (OX40) and NF-κB in the pathogenesis of lupus nephritis (LN).METHODS:Renal in situ CD134 and NF-κB expression were examined in 40 biopsy specimens from LN patients by immunohistochemistry and microwave-based immunohistochemistry, respectively. The relationship between expression of CD134 and NF-κB was analyzed.RESULTS:The expression of glomerular and tubular CD134 and NF-κB in LN were higher than that in normal control, especially in class Ⅳ LN, where there was intense staining of endothelial cell, distal tubules, and interstitial mononuclear cell. The CD134 expression of glomerular and tubular was closely related to NF-κB expression, respectively (r=0.5542, P<0.05;r=0.6279, P<0.05). CONCLUSIONS:The abnormal expression of costimulatory molecule CD134 was well evidenced in LN. Strong expression of renal in situ NF-κB was likely mediated by CD134 signal pathway, which may play an important role in the pathogenesis of LN. |
| |
Keywords: | Lupus nephritis NF-kappa B Immunohistochemistry |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
|
点击此处可从《园艺学报》下载全文 |
|