Expression of CD44s in lung cancer and its significance |
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Authors: | WANG Xiao-mei CHENG Zhi-qiang WANG Ling SU Xue-jin CHEN Zhuo-huai |
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Affiliation: | Department of Pathology, Shenzhen People's Hospital, Medical College of Jinan University, Shenzhen 518020, China |
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Abstract: | AIM: To investigate expression of CD44s in lung cancer and it's clinical significance. METHODS: A total of 117 primary lung cancer from patients were examined for CD44s expression by immunohistochemical staining. RESULTS: CD44s mostly expressed in non-small cell lung cancer (NSCLC) but not in small ecll lung cancer (SCLC), and squamous cell carcinoma(SCC) showed much stronger expression of CD44s than adenocarcinoma(ADC)(P<0.05). In comparison of the lung cancer with/ without lymph node metastasis, the latter showed stronger expression of CD44s(P<0.01). According to TNM, there was a distinct statistic difference between early stage and advanced stage(P<0.05). CONCLUSION: CD44s might be a better indicant in histological classification of lung cancer, lymph node metastasis, clinical stage and prognosis. |
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Keywords: | Antigens CD44 Lung neoplasms Immuohistochemistry |
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