Effects of the juice of Fructus Hippophae (JFH) on thrombocytopenia induced by cyclophosphamide in rats |
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| Authors: | GE Zhi-hong L IANG Yi CHEN Yun-xian WU Yao-heng ZHOU Hong LI Da |
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| Affiliation: | 1. Guangdong Province Hospital of Chinese Traditional Medicine, Guangzhou 510120, China;2. Experimental Center of the First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;3. Department of Internal Medicine, the First Affiliated Hospital, Sun-Yat-sen University, Guangzhou 510080, China |
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| Abstract: | AIM:To investigate the effects of the juice of fructus hippophae(JFH) on thrombocytopenia in rats.METHODS:Forty-eight wistar rats were divided into control group, model group, Yixuesheng-Jiaonang (YSJN) group and JFH group. Rats were injected intraperitoneally with cyclophosphamide (CTX, 30 mg/kg) or saline once a day for 3 days. And then, Saline, YSJN or JFH was administered (ig) once a day for 11 days. On the second, fouth, sixth and eighth day, the thrombocyte were counted, the mean platelet volume (MPV) and PDW were examined. On the eighth day, the cAMP, cGMP in platelets and platelet aggregation function were also examined.RESULTS:JFH could shorten the time of blood coagulation, increase the count of platelet, and enhance the platelet aggregation function. The experiment also showed that the JFH could decrease cGMP content in platelet.CONCLUSION:JFH could enhance blood coagulation and quality of platelet and prevent thrombocytopenia induced by cyclophosphamide in rats. |
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| Keywords: | Thrombocytopenia Rats Fructus Hippophaes Cyclophosphamide |
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