Mechanisms of heart failure induced by adriamycin |
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| Authors: | WU Wei-kang YANG Hui ZHAO Ming-qi |
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| Institution: | 1. Department of Pathophysiology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou 510089, China;
2. Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China |
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| Abstract: | AIM: To investigate the changes of cardiac function, oxidative stress and apoptosis in myocardium of rat model of heart failure induced by adriamycin (ADR). METHODS: At the end of the study, we observed content of malondialdehyde (MDA), activity of superoxide dismutase (SOD) and apoptosis. Expression of P53 protein and p53 mRNA were measured with immunohistochemical method and RT-PCR, respectively. RESULTS: Our data showed that content of MDA increased, activity of SOD decreased and apoptosis in myocardium happened while cardiac function decreased after ADR treatment. p53 gene expression and P53 protein obviously increased in heart failure group. CONCLUSION: There were oxidative stress and apoptosis occurred significantly in a model of heart failureinduced by ADR. p53 gene might play an important role in the apoptosis. Correlation analyses suggested that apoptosis in myocardium was related to oxidative stress in ADR-induced heart failure model. |
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| Keywords: | Doxorubicin Heart failure Stress Apoptosis Genes p53 Protein P53 |
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