Effects of alterations in extracellular pH on the respiratory burst in neutrophils |
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| Authors: | LI Yan-ling LIU Cheng-yi DUAN Rui LI Yan |
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| Affiliation: | 1. The Information Biology Group of Laboratory of Light Transmissi on Optics, South China Normal University, Guangzhou 510631, China;2. Laboratory of Laser Sport Medicine, South China Normal University, Guangzhou 510631, China;3. The Key Laboratory of Biomedical Photonics of Ministry of Education of China and State Key-Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | The respiratory burst of neutrophils is an important response in inflammation. The alterations in extracellular pH per se is not a sufficient trigger to the respiratory burst in neutrophils. While neutrophils in respose to conventional agonists, the respiratory burst in neutrophils is affected by the alterations in extracellular pH, and there is a direct relationship between intracellular and extracellular pH. O[SX(B-*3]-[]·[SX)]2 production in neutrophils is decreased while H2O2 production is increased at acidic pH. O[SX(B-*3]-[]·[SX)]2 release in neutrophils is enhanced at weak alkaline pH. Na+/H+ exchanger plays an important role in the regulation of the respiratory burst of neutrophils. |
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| Keywords: | Neutrophils Respiratory burst Extracellular space Hydrogenion concentration |
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