Gene expression of 5α-reductase (type 2) in reproductive gland of pubertal diabetic rats |
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| Authors: | LIU Su-huan WANG Zhong-shan XU Zong-ge XIN Ji-li ZUO Wen-jing |
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| Institution: | Department of Cell Biology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China |
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| Abstract: | AIM: To study the molecular mechanism of reproduction dysfunction in pubertal diabetic rat, the level of 5α-reductase (type 2) mRNA in testis, epididymis and prostate in diabetic rat was detected. METHODS: The gene expression of 5α-reductase (type 2) was detected by Northern blot. RESULTS: In the caput of the epididymis, the expression of 5α-reductase (type 2) mRNA of D and ID groups was less than that of C group. CONCLUSION: The decreased expression of 5α-reductase (type 2) results in the decreased production of dihydrotestosterone, which influences the development and function of reproduction system in pubertal rats. |
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| Keywords: | Diabetes mellitus Oxidoreductases Reproduction |
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