Anti-anaphylactic effect of Euphorbia hirta |
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| Authors: | Youssouf M S Kaiser P Tahir M Singh G D Singh S Sharma V K Satti N K Haque S E Johri R K |
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| Affiliation: | Division of Pharmacology and Natural Product Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi, India. msyousf@rediffmail.com |
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| Abstract: | The Euphorbia hirta ethanolic extract (EH A001) was found to possess a prominent anti-anaphylactic activity. A preventive effect of EH-A001 given by oral route at dose from 100 to 1000 mg/kg was observed against compound 48/80-induced systemic anaphylaxis. At the same range of dose, EH-A001 inhibited passive cutaneous anaphylaxis (PCA) in rat and active paw anaphylaxis in mice. A suppressive effect of EH-A001 was observed on the release of TNF-alpha and IL-6 from anti-DNP-HSA activated rat peritoneal mast cells. |
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| Keywords: | Euphorbia hirta Passive cutaneous anaphylaxis Active paw anaphylaxis |
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