Safety of alternate-day treatment with TS-1TM
(tegafur/gimeracil/oteracil) in tumor-bearing dogs: a pilot study |
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| Authors: | Yuta NISHIYAMA Yasuhiro FUKUYAMA Takuya MARUO Shinichiro YODA Masataka IWANO Shinpei KAWARAI Hideki KAYANUMA Kensuke ORITO |
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| Institution: | 1)Veterinary Teaching Hospital, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan;2)Laboratory of Veterinary Radiology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan;3)Laboratory of Veterinary Physiology II, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo, Sagamihara, Kanagawa 252-5201, Japan |
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| Abstract: | Tegafur is a prodrug of fluoropyrimidine 5-fluorouracil (5-FU), while TS-1TM is an oral fixed-dose combination of three active drugs, tegafur, gimeracil, and oteracil. This pilot study evaluated the safety of tegafur/gimeracil/oteracil in the treatment of cancers in dogs. Tegafur/gimeracil/oteracil was administered orally at a mean dose of 1.1 mg/kg twice daily on alternate days, Monday-Wednesday-Friday, every week to 11 dogs with tumors. Partial response and stable disease were observed in one dog each, whereas six exhibited progressive disease. Three dogs were not assessed. Adverse events, the most serious being grade 2, were noted in seven dogs. Adverse events were acceptable, and the drug was effective in some dogs. Therefore, tegafur/gimeracil/oteracil may be useful for treating malignant solid tumors in canines. |
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| Keywords: | dog 5-fluorouracil TS-1 Teysuno tumor |
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