Quantitative mass spectrometry identifies insulin signaling targets in C. elegans |
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Authors: | Dong Meng-Qiu Venable John D Au Nora Xu Tao Park Sung Kyu Cociorva Daniel Johnson Jeffrey R Dillin Andrew Yates John R |
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Institution: | Scripps Research Institute, La Jolla, CA92037, USA. |
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Abstract: | DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin. |
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