Antidiarrhoeal activity of Strychnos potatorum seed extract in rats |
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| Authors: | Biswas Swati Murugesan T Sinha Sanghamitra Maiti Kuntal Gayen Jiaur Rahaman Pal M Saha B P |
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| Institution: | Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India. |
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| Abstract: | The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling. |
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