| 人参皂苷Rb3对实验性心肌缺血的保护作用 |
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| 引用本文： | 孙伟伦,李凤,刘一鸣,曲绍春,于晓风,睢大筼.人参皂苷Rb3对实验性心肌缺血的保护作用[J].人参研究,2012,24(3):2-4. |
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| 作者姓名： | 孙伟伦 李凤 刘一鸣 曲绍春 于晓风 睢大筼 |
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| 作者单位： | 吉林大学药学院药理教研室,吉林长春,130021 |
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| 摘 要： | 目的研究人参皂苷Rb3(G-Rb3)对实验性心肌缺血的保护作用,并与西洋参茎叶20S-原人参二醇皂苷(PQDS)进行比较。方法昆明种小鼠皮下注射异丙肾上腺素后放入盛有钠石灰的250ml广口瓶内,加盖密封后记录小鼠存活时间;Wistar大鼠舌下静脉注射垂体后叶素后观察心电图变化程度。结果 G-Rb320、40mg/kg及PQDS 50mg/kg对皮下注射异丙肾上腺素缩短小鼠在常压缺氧状态下的存活时间均具有明显对抗作用;G-Rb3 14、28mg/kg及PQDS 35mg/kg均可明显减轻垂体后叶素诱发的大鼠急性心肌缺血心电图(ST段抬高及T波高耸)变化程度。结论 G-Rb3对实验性心肌缺血具有明显保护作用,其作用强度与维拉帕米相当。
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| 关 键 词： | 人参皂苷Rb3 PQDS 异丙肾上腺素 垂体后叶素 心电图 |
Protective Effect of Ginsenoside Rb3 on Experimental Myocardial Ischemia |
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| Authors: | SUN Weilun LI Feng LIU Yiming YU Xiaofeng QU Shaochun SUI Dayun |
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| Institution: | (Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China) |
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| Abstract: | Objective To study the protective effect of Ginsengoside Rb3（G-Rb3） on the experimental myocardial ischemia and compare with Panas Quinquefolium 20s-protopanoxadiol Saponin（PQDS）.Methods ICR mice were put in wide-mouthed bottle with 250ml natrica calx after injecting subcutaneously isoprenaline and survival time of mice was recorded after seal with lid;The changes of electrocardiogram in Wistar rats were observed after injecting hypophysin with sublingual vein.Results G-Rb3 20,40mg/kg and PQDS 50mg/kg could both prolong significantly survival time of mice in normal pressure anoxia state;G-Rb3 14,28mg/kg and PQDS 35mg/kg could both lessen significantly changes of acute myocardial ischemic electrocardiogram induced by hypophysin in rats.Conclusion G-Rb3 have significantly a protective effect on experimental myocardial ischemia,which are the same strength with verapamil. |
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| Keywords: | G-Rb3 PQDS isoprenaline hypophysin electrocardiogram |
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