Research Progress on Main Pathogen Resistance of Dairy Cows and Control Technology

At present, the usual and effective method of treating the cow disease caused by pathogens is still antimicrobials. The irrational use of antimicrobials makes bacteria produce resistance, and has become a global problem. The main pathogens of dairy cows include Staphylococcus aureus, Streptococcus, Escherichia coli and so on, which show a trend of multiple drug resistance. It not only brings great challenges for the clinical treatment of dairy cow, but also gives a threat to human health. Antimicrobial resistance is far more than the speed of people developing antimicrobials. Therefore, it is necessary to maintain the efficacy of existing antimicrobials for treating infections. On the one hand, we should master the bacterial resistance mechanism, such as bacterial molecular resistance mechanism, antibiotic efflux mechanism or reducing the intake mechanism, biofilm, so as to help us find the adequate therapeutics; On the other hand, taking different measures to reduce the emergence bacterial resistance, such as plasmid elimination, antibiotic substitutes, the development of efficient and safe antimicrobials, clinical rational drug (combined treatment) and so on. This article reviews dairy cow's main pathogen resistance, drug resistance mechanism, drug resistance control technology and make a prospect for this. It would provide reference for reducing the drug resistance, regulating the use of antimicrobials and improving the therapeutic effect.