Research Progress on Animal Models of Bama Miniature Pigs in the Field of Medicine

Bama miniature pigs, which are local high-quality species of China, have the advantages of genetic stability, ideal hair distribution, microsomatia, prolificacy, low fodder demand, strong disease resistance, and they are similar to human beings in aspects of physiology, anatomical structure, drug metabolism, biochemical indicators, disease mechanism, etc. Bama miniature pigs have been used in the wide fields of medical research, such as cardiovascular system, skin plastic, endocrine and metabolism, digestive system, oral medicine, heterograft, Chinese medicine, anesthesiology, nervous system, etc., and been applied to establish the animal models which are similar to human diseases, such as myocardial ischemia, coronary micro-embolization, atrial septal defect, atherosclerosis, skin injury, transdermal drug, metabolic syndrome, diabetes mellitus and complications, obstructive jaundice, chronic pancreatitis, liver cirrhosis, liver radiofrequency ablation, periodontal tissue inflammation, mandibular defect, heterogeneous organ/cell transplantation, syndrome of Chinese medicine, anesthesia, cerebral ischemia, stent implantation, shock, etc. Bama miniature pigs, as an ideal experimental animal, have broad application prospects in biomedical research.In this article,we mainly summarized the progress of Bama miniature pigs in the field of medicine, to understand the types, construction methods and pathological characteristics of Bama miniature pigs disease models, which contribute to further explore the specific etiology, pathogenesis, complications, prevention and control measures, etc., and laid the scientific foundation for expanding the research scope and improving the medical level.