BYHWD promotes endothelial progenitor cells to repair damaged vascular endothelium |
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| Authors: | ZHANG Wei HE Bing LI Liang LI Fei CAO Lang LIU Xiao-dan DENG Chang-qing |
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| Institution: | 1. The Affiliated Yueyang Hospital of Hunan University of Chinese Medicine, Yueyang 414000, China;
2. The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410005, China;
3. Institute of Integrated Chinese and Western Medicine of Hunan University of Chinese Medicine, Changsha 410208, China |
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| Abstract: | AIM: To investigate the role of Buyanghuanwu decoction (BYHWD) in promoting endothelial progenitor cells (EPCs)-induced recovery of damaged vascular endothelium. METHODS: The endothelial damaged rats were lavaged with BYHWD and injected with EPCs through vena caudalis. The repaired situation of damaged endothelium was observed. RESULTS: Compared with EPCs group and BYHWD group, the endothelial thickness was reduced, the levels of calcium, triglycerides and total cholesterol were decreased, but the high density lipoprotein levels were increased. In addition, the protein expression of vascular endothelial nitric oxide synthase and vascular stromal cell-drived factor-1 was sig-nificantly increased, but the expression of CXC chemokine receptor-4 was significantly reduced in BYHWD+EPC group. CONCLUSION: BYHWD promotes EPCs repairing damaged endothelium, the mechanism may be related to improve the internal environment and promotes the EPCs homing. |
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| Keywords: | Buyanghuanwu decoction Endothelial progenitor cells Vascular endothelium Endothelial nitric oxide synthase Stromal cell-derived factor-1 CXC chemokine receptor-4 |
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