Effect of PTP4A3 gene on tumor growth and metastasis |
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| Authors: | GUO Yu-bing XU Dan SUN Ye-qing ZHAO Bin |
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| Affiliation: | 1.Dalian Maritime University, Environmental Science and Engineering College, Institute of Environmental Systems Biology, Dalian 116026, China;2.Chinese Academy of Science, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Science, Beijing 100085, China |
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| Abstract: | PTP4A3 is an oncogene, which encodes phosphatase of regenerating liver (PRL)-3 protein that is a metastasis-associated phosphorylase. At present, a number of studies have found that it promotes cell proliferation, cell motility, cell invasion, tumor metastasis and epithelial-mesenchymal transition. Therefore, it is inseparable with the occurrence and development of cancer. Here, we summarize the relationship betweenPTP4A3 gene and the occurrence and development of cancer, the alteration ofPTP4A3gene expression and the functional role ofPTP4A3 gene in a variety of cancers. This review will help us to understand the correlation betweenPTP4A3 gene and cancer as well as the mechanism of signaling pathway, providing new insights ofPTP4A3 gene targeting strategy for treating cancer. |
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| Keywords: | PTP4A3gene Cell proliferation Cell motility Tumor invasion Tumor metastasis Epithelial-mesenchymal transition |
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