Effects of Different Milk Samples on Sensitization in BALB/c Mice |
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Authors: | BAI Na MING Liang GAO Wan-ting GUO Fu-cheng QIAO Xiang-yu CHAOGE Sulide GUO Yan YI Ri-gui LIU Dong-hui JI Rimutu |
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Affiliation: | 1. Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China;2. Camel Research Institute of Inner Mongolia, Alex 737300, China |
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Abstract: | In order to study the allergenicity of camel milk,cow milk and human milk,sixty BALB/c mice were randomly divided into β-lactoglobulin (β-lg) group (positive control group),cow milk group,camel milk group,human milk group and blank group (negative control group). Each group of mice received 1 mg/g BW samples and 0.3 μg/g cholera toxin (CT) per week,while mice in control group were received PBS and CT. After six weeks of intragastric administration,some allergic symptoms,the serum specific immunoglobulin E (IgE) and immunoglobulin G1 (IgG1) levels,plasma histamine levels and vascular permeability were detected. The results showed that the body weight of mice in camel milk,human milk and blank groups were normally increased,while that in β-lg and cow milk groups tended to slow down. The serum-specific IgE,IgG1 levels and histamine level in β-lg and cow milk groups were extremely significantly higher than blank group (P<0.01),the vascular permeability was increased,and the allergy symptoms were obvious. While the specific IgE and IgG1 levels of camel milk group were extremely significantly lower than cow milk group (P<0.01),but there were no significant difference with human milk group (P>0.05),and the allergy symptoms were mild. This study showed that the sensitization of camel milk was lower than cow milk,and similar to human milk. |
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Keywords: | BALB/c mice camel milk cow milk allergy β-lg |
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