Research Progress on Molecular Etiology and Pathogenesis for African Swine Fever Virus |
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Authors: | OU Yun-wen YAN Chuan-zhong ZHANG Jie MA Bing DAI Jun-fei ZHANG Yong-guang JIA Ning |
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Institution: | 1. Animal Disease Prevention and Control Center, Animal Husbandry and Food Bureau of Kaijiang Country, Dazhou 635000, China;
2. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China;
3. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China |
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Abstract: | African swine fever (ASF) is a devastating disease caused by African swine fever virus (ASFV), characterized by acute feature, high fever, high mortality and other characteristics. ASF mainly outbreaks in African, Eastern Europe countries, Russia and Caucasus region. At present, there are no vaccine available and effective control strategies against ASFV spread, therefore, ASF has a serious impact on the pig industry in the affected countries. The major target cells of the virus are swine reticuloendothelial cells and monocyte-macrophage cells. ASFV can result in apoptosis and affect the host's immune system, and then show the characteristics of the corresponding disease. ASFV has the characteristics of large genome, more genotype and more variability. In this paper, the molecular etiology and pathogenesis of ASFV are reviewed, so as to provide theoretical basis for prevention and control of ASF. |
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Keywords: | African swine fever virus (ASFV) molecular etiology host pathogenesis |
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