半胱胺对小鼠血清生长激素、甲状腺素、促甲状腺素及胰岛素水平的影响

探索半胱胺(cysteam ine,CS)对小鼠血清激素水平的影响。按50 mg/kg BW CSH(cysteam ine hydrochlo-ride)和100 mg/kg BW CSH的配比浓度灌服小鼠,采用R IA方法检测血清生长激素、甲状腺素、促甲状腺素和胰岛素水平。结果显示:50 mg/kg BW CSH处理组,血清GH、T3水平显著升高(P<0.05),T4有所上升(P>0.05),TSH、胰岛素呈下降趋势(P>0.05);100 mg/kg BW CSH处理组,血清GH、T3上升极显著(P<0.01),T4、胰岛素上升明显(P<0.05),TSH明显下降(P<0.05),另外,两试验组间GH存在统计学差异(P<0.05)。CS能改善小鼠血清激素水平,增强机体代谢机能。

Effects of Cysteamine on GH,TSH,T3,T4 and Insulin of Serum of Mice

To study the effects of cysteamine on hormone levels of serum of mice.Mice were infused with 50 mg/kg BW CSH and 100 mg/kg BW CSH respectively.Radioimmunoassay was used to detect the levels of GH,T3,T4,TSH and insulin in serum of mice.Results show that: In the 50 mg/kg BW CSH treatment group,levels of serum GH and T3 increased significantly(P<0.05)and that of T4 increased slowly(P>0.05),however,concentrations of TSH and insulin decreased slightly(P>0.05).In the 100 mg/kg BW CSH treament group,cysteamine hydrochloride augmented concentrations of GH and T3(P<0.01)and those of T4 and insulin(P<0.05),but decreased mean TSH level significantly(P<0.05).In addition,between the two experiment groups there was an obvious difference in GH concentrations(P<0.05).CSH could improve serum hormone levels and enhance physioligical metabolism of mice.