| 鸡大肠杆菌重组1型菌毛疫苗的免疫原性 |
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| 引用本文： | 甘黎明,蒋加进,陈钟鸣,张志成,戴鼎震.鸡大肠杆菌重组1型菌毛疫苗的免疫原性[J].安徽农业科学,2011,39(36):22346-22347. |
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| 作者姓名： | 甘黎明 蒋加进 陈钟鸣 张志成 戴鼎震 |
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| 作者单位： | 金陵科技学院动物科学与技术学院,江苏南京,211196;金陵科技学院动物科学与技术学院,江苏南京,211196;金陵科技学院动物科学与技术学院,江苏南京,211196;金陵科技学院动物科学与技术学院,江苏南京,211196;金陵科技学院动物科学与技术学院,江苏南京,211196 |
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| 基金项目： | 江苏省自然科学基金资助(BK2008059) |
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| 摘 要： | 目的]制备鸡大肠杆菌重组1型菌毛疫苗，并探索其免疫原性。方法]从含1型菌毛的基因重组菌株CZYRl0与野生型鸡大肠杆菌分离株YR（018）中提取1型菌毛，制备菌毛油乳剂疫苗。通过对鸡群的攻毒试验，探讨该疫苗的免疫原性。结果]重组1型菌毛蛋白具有免疫保护作用。重组1型菌毛疫苗的保护力比分离的鸡大肠杆菌1型菌毛疫苗保护率低，但差异不显著（P〉0．05）。结论]该研究可为鸡大肠杆菌病的免疫防治提供依据。
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| 关 键 词： | 鸡大肠杆菌 重组1型菌毛疫苗 免疫原性 |
Immunogenicity of Vaccine against Recombinant Type 1 Pilus of Avian Escherichia coli in Chickens |
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| Institution: | GAN Li-ming et al (Jinling Institute of Technology,Nanjing,Jiangsu 211196) |
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| Abstract: | Objective] To prepare vaccine against recombinant type 1 pilus protein of avian Escherichia coli and to detect its immunogenicity in chickens.Method] The type 1 pilus was respectively isolated from the recombinant bacteria CZYR10 strain and wild avian Escherichia coli YR(018) strain and used to prepare oil-emulsified vaccine.The immunogenicity of the developed vaccine was detected in chickens using challenge test.Result] The recombinant type 1 pilus protein had immunoprotective efficacy.The recombinant type 1 pilus protein had weaker protective efficacy then the isolated type 1 pilus protein,but the difference was not significant.Conclusion] The study provides a reference for immunization and control of chicken colibacillosis. |
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| Keywords: | Avian Escherichia coli Recombinant type 1 pilus Immunogenicity |
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