| 孔枕益智片质量标准研究 |
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| 引用本文： | 左红香,金勇,张成义,马继梅. 孔枕益智片质量标准研究[J]. 吉林林学院学报, 2010, 0(5): 420-423 |
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| 作者姓名： | 左红香 金勇 张成义 马继梅 |
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| 作者单位： | [1]北华大学药学院,吉林吉林132013 [2]延边大学药学院,吉林吉林133000 [3]江苏苏中药业集团股份有限公司,江苏姜堰225500 |
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| 摘 要： | 目的建立孔枕益智片的质量标准.方法采用TLC法对孔枕益智片中石菖蒲和远志两味药材进行了定性鉴别;采用HPLC法对孔枕益智片中五味子醇甲进行了含量测定.色谱条件：YMC-C18色谱柱（250 mm×4.6 mm,5μm）,流动相为甲醇-水（65∶35）,流速为0.8 mL/min,柱温为25℃,检测波长为250 nm.结果供试品色谱中,在与对照药材色谱相应的位置上显相同颜色的斑点,阴性对照色谱在相应位置上无斑点.五味子醇甲在0.04～0.32μg内呈良好的线性关系（r=0.999 9）,平均加样回收率为98.68%,RSD为0.46%（n=5）.结论本方法简便、快速,准确、可靠,可有效地控制孔枕益智片的质量.
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| 关 键 词： | 孔枕益智片 薄层色谱法 高效液相色谱法 石菖蒲 远志 五味子醇甲 |
On the Quality Standard of Kongzhenyizhi Tablet |
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| ZUO Hong-xiang,JIN Yong,ZHANG Cheng-yi,MA Ji-mei. On the Quality Standard of Kongzhenyizhi Tablet[J]. , 2010, 0(5): 420-423 |
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| Authors: | ZUO Hong-xiang JIN Yong ZHANG Cheng-yi MA Ji-mei |
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| Affiliation: | 1.Pharmacy College of Beihua University,Jilin 132013,China;2.Pharmacy College of Yanbian University,Yanbian 133000,China;3.Suzhong Pharmaceutical Group Co.Limited,Jiangyan 225500,China) |
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| Abstract: | Objective To establish the quality standard of Kongzhenyizhi tablet.Method Rhizoma acori tatarinowii and Radix polygalae were identified by TLC.The content of Schizandrol A was determined by HPLC on YMC-C18 column（250 mm×4.6 mm,5 μm）.The mobile phase was methanol-water（65∶35）.The flow rate was 0.8 mL/min.The oven was 25 ℃.The detection wavelength was 250 nm.Results The method showed that a good linear correlation for the Schizandrol A existed in the range of 0.04 to 0.32 μg（r=0.999 9）.The average recovery of Schizandrol A was 98.68% and RSD was 0.46%（n=5）.Conclusion The method is simple,accurate,repeatable,and precise,and can be used for the quality control of Kongzhenyizhi tablet. |
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| Keywords: | Kongzhenyizhi tablet TLC HPLC Rhizoma acori tatarinowii Radix polygalae Schizandrol A |
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