Potential insulin secretagogue effects of isovitexin and swertisin isolated from Wilbrandia ebracteata roots in non-diabetic rats |
| |
| Authors: | Poliane Folador Luisa Helena Cazarolli Andressa Crneo Gazola Flvio Henrique Reginatto Eloir Paulo Schenkel Ftima Regina Mena Barreto Silva |
| |
| Institution: | a Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, SC, Brazil;b Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, SC, Brazil |
| |
| Abstract: | The antihyperglycemic effect and mechanism of action of extracts, fractions and compounds from Wilbrandia ebracteata was studied. The crude extract reduced the glycemia, increased glycogen content and serum insulin in hyperglycemic rats. Also, a significant effect was observed with the n-butanol and metanol subfraction. However, the antihyperglycemic effect of the n-butanol fraction was not observed in diabetic rats. The C-glycosylflavones isovitexin and swertisin showed a strong antihyperglycemic action compared with the extracts and fractions. These results show that the extracts, fractions, and isolated C-glycosylflavones have an antihyperglycemic action that was reinforced by the stimulation on in vivo insulin secretion. |
| |
| Keywords: | Wilbrandia ebracteata Flavonoids Glycemia Isovitexin Swertisin Insulin |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
