Half-lives of sulphadoxine and trimethoprim after a single intravenous infusion in cows |
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| Authors: | D Davitiyananda F Rasmussen |
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| Affiliation: | 1.Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Copenhagen, DK-1870 Denmark ;2.Department of Pharmacology, Veterinary Faculty, Bangkok, Thailand, P.R. China |
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| Abstract: | DAVITIYANANDA, DANIS and FOLKE RASMUSSEN: Half-lives of sulphadoxine and trimethoprim after a single intravenous infusion in cows. Acta vet. scand. 1974, 15, 356–365. — The half-life of sulphadoxine in plasma (11 hrs.) is much longer than that of trimethoprim (50–103 min.) and in accordance to this traces of sulphadoxine are demonstrated in the milk 3 days after the infusion, while trimethoprim could not be detected in milk 2 days after the infusion. The apparent volume of distribution is 0.37 for sulphadoxine and 1.14 for trimethoprim, i.e. 37 % and 114 % of the body weight, respectively.sulphadoxine; trimethoprim; half-life; cow. |
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