13-Epi-9-deacetoxyxenicin,a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea) |
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Authors: | Bruce F Bowden Bernard J Cusack Alissa Dangel |
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Institution: | Department of Chemistry, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Qld., 4811, Australia. Tel. +61 747 814533, Fax +61 747 816078 |
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Abstract: | An investigation of the soft coral Asterospicularia laurae collected on the Great Barrier Reef, Australia, afforded the cytotoxic diterpene 13-epi-9-deacetoxyxenicin (1) in addition to the known metabolites 13-epi-9-deacetylxenicin (2) and gorgosterol. 13-Epi-9-deacetoxyxenicin readily underwent an autoxidation reaction in solution to afford a single product, the hydroperoxide 3. Structures, stereochemistry, and NMR assignments were established by high resolution NMR spectroscopy and by comparison with published data for known compounds. |
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Keywords: | Cytotoxic xenicane diterpene soft coral Asterospicularia |
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