| 新型腙类衍生物的合成及其生物活性 |
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| 引用本文： | 汪飞,曹瑾,袁莉萍,郭庆铭,倪长春,沈宙,张一宾. 新型腙类衍生物的合成及其生物活性[J]. 农药学学报, 2006, 8(2): 176-179 |
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| 作者姓名： | 汪飞 曹瑾 袁莉萍 郭庆铭 倪长春 沈宙 张一宾 |
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| 作者单位： | 华东理工大学,药学院,上海,200237;上海市农药研究所,上海,200032 |
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| 基金项目： | 国家“十五”科技攻关计划(2004BA308A22-3)，上海市科技攻关计划(034319251)，国家重点基础研究发展计划(“973”计划)资助项目2003CB114401) |
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| 摘 要： | 利用3-(N-甲基-N-甲氧基氨基)-1-芳基-1-丙酮腙与酰氯反应,合成了14个新型N-酰基-3-(N-甲基-N-甲氧基氨基)-1-芳基-1-丙酮腙化合物,其化学结构经1H核磁共振和元素分析确证。初步的生物活性测试结果表明,部分化合物在50 mg/L时对淡色库蚊Culex pipiens pallens的致死率为95%~100%;化合物 c7 在1 000 mg/L时对粘虫Leucania separata Walke 的致死率达100%。
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| 关 键 词： | 酰化反应 芳基丙酮腙 合成 生物活性 |
| 文章编号： | 1008-7303(2006)02-0176-04 |
| 收稿时间： | 2005-12-12 |
| 修稿时间： | 2006-03-27 |
Synthesis and Bioactivity of a Series of Novel Hydrazone Derivatives |
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| WANG Fei,CAO Jin,YUAN Li-ping,GUO Qing-ming,NI Chang-chun,SHEN Zhou and ZHANG Yi-bin. Synthesis and Bioactivity of a Series of Novel Hydrazone Derivatives[J]. Chinese Journal of Pesticide Science, 2006, 8(2): 176-179 |
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| Authors: | WANG Fei CAO Jin YUAN Li-ping GUO Qing-ming NI Chang-chun SHEN Zhou ZHANG Yi-bin |
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| Affiliation: | 1.East China University of Science and Technology, Pharmaceutical Institute,Shanghai 200237, China2.Shanghai Pesticide Research Institute, Shanghai 200032, China |
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| Abstract: | In search of novel pesticide compound with high bioactivity,fourteen new N-3-(N-methoxy-N-methyl-amino)-1-arly-propylidene-hydrazazide derivatives have been designed and synthesized by the reaction of N- -O,N-dimethyl-hydroxylamine with different acyl chlorides. Their structures have been confirmed by 1H NMR and elemental analysis. The preliminary biological activity showed that some compounds possessed insecticidal activities against Culex pipiens pallens and Leucania separata Walke. The mortality ratio of some compounds against C. pipiens pallens coqillett were 95%~100% at concentration of 50 mg/L. The mortality ratio of c7 against L. separata was 100% at 1 000 mg/L. |
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| Keywords: | acylation hydrazone synthesis bioactivity |
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