| 不同物种RAB27A基因完整编码区生物信息学分析 |
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| 引用本文： | 王建涛,李祥龙,周荣艳,冯付军,郭秀丽,唐春娟,秦洁.不同物种RAB27A基因完整编码区生物信息学分析[J].中国农学通报,2007,23(11):64-67. |
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| 作者姓名： | 王建涛 李祥龙 周荣艳 冯付军 郭秀丽 唐春娟 秦洁 |
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| 作者单位： | 河北农业大学动物科技学院,保定,071001 |
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| 基金项目： | 河北农业大学校科研和教改项目;科研发展基金 |
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| 摘 要： | 应用比较基因组学和生物信息学方法比较分析了人、黑猩猩、恒河猴、家鼠、挪威鼠、狗、猪、牛、马、短尾负鼠、鸡和非洲爪蛙RAB27A基因完全编码区(cds),并对该基因的遗传多样性及分子系统发育进行了分析。结果表明,来自12个物种的52条基因序列检测到239个多态位点,共生成17种单倍型。RAB27A基因物种内保守性较强,但在物种间核苷酸多样性和氨基酸多样性相对丰富。
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| 关 键 词： | 物种 RAB27A基因 变异 |
| 修稿时间： | 2007-07-18 |
Bioinformatics Analysis Based on Complete Coding Regions of RAB27A Gene among Species |
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| Wang Jiantao,Li Xianglong,Zhou Rongyan,Feng Fujun,Guo Xiuli,Tang Chunjuan,Qin Jie.Bioinformatics Analysis Based on Complete Coding Regions of RAB27A Gene among Species[J].Chinese Agricultural Science Bulletin,2007,23(11):64-67. |
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| Authors: | Wang Jiantao Li Xianglong Zhou Rongyan Feng Fujun Guo Xiuli Tang Chunjuan Qin Jie |
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| Institution: | College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001 |
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| Abstract: | In this study,the complete cds of the RAB27A gene sequences of Homo sapiens,Pan troglodytes,Macaca mulatta,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Bos taurus,Equus caballus,gray short-tailed opossum,Gallus gallus and western clawed frog were analyzed using the method of comparative genomics and bioinformatics.The genetic diversity and molecular phylogeny were also analyzed.The results showed that a total of 239 polymorphic sites were detected from 52 sequences of 12 species,from which 17 hapolotypes were sorted.Comparing with its higher conservative within species,it comes to relative diversity in RAB27A for both nucleotide and amino acid among species. |
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| Keywords: | species RAB27A gene variation |
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