血清可溶性细胞间粘附分子在大肠癌患者组织中的检测及其意义

目的:探讨血清可溶性细胞间粘附分子1(sICAM-1)的检测在大肠癌患者中的临床意义。方法:采用双抗体夹心ELISA法检测50例大肠癌、30例大肠良性病变及30例健康体检者血清sICAM-1水平,并比较大肠癌患者术前、术后,转移、无转移sICAM-1水平变化。结果:大肠癌患者血清sICAM-1水平明显高于良性病变患者及正常人(P<0.01);大肠癌患者术后血清sICAM-1水平较术前明显下降(P<0.01);有转移的大肠癌患者血清sICAM-1水平高于无转移的患者(P<0.01)。结论:血清sICAM-1水平与大肠癌的发生、发展密切相关,可作为大肠癌新的检测指标之一。

Measurement and clinical significance of a soluble adhesion molecule (sICAM-1) in patients with colorectal cancer

Objective: To investigate the clinical significance of a soluble adhesion molecule (sICAM-1) by determining its serum level in patients with colorectal cancer. Methods: The levels of sICAM-1 were measured with the double antibody sandwich enzyme-linked immuno-adsorbent assay in 50 patients with colorectal cancer, 30 patients with benign colorectal lesions and 30 cases without colorectal disease; the changes of sICAM-1 levels were observed in cancer patients before and after operation, and in patients with and without metastasis, respectively. Results: The serum levels of sICAM-1 were significantly higher in colorectal cancer patients than in those without colorectal disease or with benign colorectal lesions (P<0.01) , in patients before operation than in them after operation (P<0.01), and in patients with metastasis than in those without (P<0.01) . Conclusion: The sICAM-1 might closely associate with the occurrence and development of colorectal cancer and might serve as a useful marker for detection of colorectal cancer.