苏子提取物对高脂血症家兔血脂及脂质过氧化的影响

目的]研究苏子提取物（EPS）对家兔高脂血症的防治作用。方法]采用高脂饮食建立家兔高脂血症模型,分别测定正常对照组,高脂模型组,苏子提取物低剂量组（0.1 g/ml）、中剂量组（0.5 g/ml）、高剂量组（1.0 g/ml）血清中的TC、TG、LDL-C、HDL-C及肝匀浆MDA含量及SOD活性。结果]EPS能显著降低血清中的TC、TG、LDL-C,提高血清中HDL-C的含量,降低肝匀浆MDA的含量,提高SOD的活性。结论]EPS具有一定的调节血脂及抗脂质过氧化作用。

Effects of Perilla Seed Extracts on the Blood Fat and Lipid Peroxidation of Rabbit with Hyperlipidemia

Objective] The aim was to observe the control effect of perilla seed extracts(EPS) on the hyperlipidemia of rabbits.Method] The high fat and cholesterol diet were adopted to build the hyperlipidemia model of rabbit.The rabbits were randomly and equally divided into 5 groups which were NC(normal control) group,HLM(high lipid model) group,EPSⅠ,EPSⅡ and EPS Ⅲ group(low,middle,high dose of 0.1 g/ml,0.5 g/ml and 1.0 g/ml EPS respectively).The contents of TC,TG,LDL-C and HDL-C in serum and the contents of MDA,the activity of SOD in liver homogenate were detected respectively.Result]The EPS groups could significantly decrease the contents of TC,TG and LDL-C and improve the contents of HDL-C;reduce the contents of MDA and improve the activity of SOD.Conclusion] EPS could regulate blood fat and control act lipid peroxidation.