洁霉素在马体内的代谢动力学

本文分析了洁霉素在健康马体内的代谢动力学过程。肌肉注射后血清药物浓度——时间曲线符合开放式二室模型。洁霉素的药代动力学参数如下:药物的分布半衰期(t(1/2α))为0.35±0.34小时,生物半衰期(t(1/2)β)) 为8.08±0.73小时,吸收半衰期(t(1/2)k_a) 为0.14±0.03小时,药物在中央室与周边室间分布的转运速率常数 k_(12)为2.229±1.551(h~(-1))与 k_(21)为0.5129±0.1981(h~(-1)),清除率(CLB)为0.1803±0.0808(ml/kg·h),药物从中央室清除的消除速率常数(kel)为0.5784±0.5644(h~(-1))。根据单剂量给药的参数预测了多剂量给药间隔。给药后12小时的稳态最高与最低浓度为9.66(μg/ml)与6.23(μg/ml),积累系数 R 为1.56。本研究确定洁霉素的给药间隔时间为12小时。

PHARMACOKINETICS OF LINCOMYCIN IN HORSES

This topic studied pharmacokinetic process of lincomycin in healthyadult horses.Post-intramuscular serum drug concentraion versus time curvewas fitted to two-compartment open model.Pharmacokinetic parameters of lincomycin were as follows:The distributionhalf-times (t1/2α) of the drug was 0.35±0.34hour,the biological half-life of fhedrug(t1/2β) was 8.08±0.73 hr,the absorption half-time of lincomycin (t1/2kA) was0.14±0.03hr,the first-order transfer rate constant for drug distribution betweenthe central and peripheral compartments k_(12) was2.2290±1.5521 (h~(-1)) and k_(21)was 0.5129±0 1981 (h~(-1)),the body clearance (?)was 0.1803±0.0808 (ml/kg·h),the first-order elimination rate constant for disappearance of drug from thecentral compartment kel was 0.5784±0.5644 (h~(-1)).Multiple dosage regimen was predicted on the basis of parameters of singledose.The maximum and minimum steady state level at posttreatment hour 12were 9.66 (μg/ml) and 6.23 (μg/ml),the accumulation factor (R) was 1.56.The investigation established that the dosage intervals of lincomycin were12 hours.