New cytotoxic quinolone alkaloids from fruits of Evodia rutaecarpa |
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Authors: | Huang Xin Li Wei Yang Xiu-Wei |
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Institution: | State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China. huangx_132@163.com |
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Abstract: | Three new quinolone alkaloids, 1-methyl-2-7-hydroxy-(E)-9-tridecenyl]-4(1H)-quinolone (1), 1-methyl-2-(Z)-4-nonenyl]-4(1H)-quinolone (2), 1-methyl-2-(1E,5Z)-1,5-undecadienyl]-4(1H)-quinolone (3) and one new natural product, 1-methyl-2-(E)-1-undecenyl]-4(1H)-quinolone (4), were isolated from the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth., along with thirteen known compounds (5-17). In addition, one new artificial product, 1-methyl-2-7-carbonyl-(E)-9-tridecenyl]-4(1H)-quinolone (1A) was also obtained. The structures of these compounds were determined by spectroscopic analyses. The cytotoxic activities of all of the compounds against the human cancer cell lines HL-60, N-87, H-460, and Hep G(2) cells were evaluated by MTT assay. The results showed that these alkaloids inhibited cell proliferation with IC(50) values between 14μM and 22μM. |
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Keywords: | Evodia rutaecarpa Rutaceae Quinolone alkaloids Cytotoxic activity MTT assay |
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