Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets |
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| Authors: | Paweł Paśko Małgorzata Tyszka-Czochara Agnieszka Galanty Joanna Gdula-Argasińska Paweł Żmudzki Henryk Bartoń Paweł Zagrodzki Shela Gorinstein |
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| Institution: | 1.Department of Food Chemistry and Nutrition, Medical College,Jagiellonian University,Kraków,Poland;2.Department of Pharmacognosy, Medical College,Jagiellonian University,Kraków,Poland;3.Department of Radioligands, Medical College,Jagiellonian University,Kraków,Poland;4.Department of Medicinal Chemistry, Medical College,Jagiellonian University,Kraków,Poland;5.Institute for Drug Research, School of Pharmacy, Hadassah Medical School,The Hebrew University,Jerusalem,Israel |
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| Abstract: | The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets. Broccoli sprouts were selectively cytotoxic on HepG2 and SW480 cells, with proapoptotic effect for the latter, while the florets were less selective, but more active, with profound proapoptotic effect for HepG2 cells (77.4%). Thus, lyophilized broccoli sprouts may be effectively used in dietary chemoprevention. |
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