The comparative hypoxaemic effect of four α2 adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep |
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| Authors: | CS CELLY WN McDONELL SS YOUNG & WD BLACK |
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| Institution: | Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada N1G 2W1,;Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1,;Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033, USA |
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| Abstract: | In the present study, the hypoxaemic potential of four α2 agonists possessing different selectivity for α2 adrenoceptors and of a saline placebo was studied in five clinically healthy sheep using a randomized Latin square design and equipotent sedative doses. Baseline values for heart rate (HR), mean arterial pressure (MAP), arterial oxygen (PaO2) and carbon dioxide (PaCO2) tensions, respiration rate and maximum change in pleural pressure (ΔPpl) were obtained, followed by the intravenous administration of either: xylazine (150 μg/kg); romifidine (50 μg/kg); detomidine (30 μg/kg); medetomidine (10 μg/kg) or placebo. Subsequent recordings were made up to 60 min after drug administration. No significant (P  alterations in any variable occurred with placebo. All the α<sub>2</sub> agonists significantly (<i>P</i> <img loading=) | |
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