| 鸡新城疫和传染性法氏囊病灭活疫苗抗原量对鸡细胞免疫的影响 |
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| 引用本文： | 黄兵,王莉莉,张秀美. 鸡新城疫和传染性法氏囊病灭活疫苗抗原量对鸡细胞免疫的影响[J]. 中国预防兽医学报, 2000, 22(6): 433-435 |
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| 作者姓名： | 黄兵 王莉莉 张秀美 |
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| 作者单位： | [1]山东农科院家禽研究所,济南 [2]南京农业大学动物医学院,南京 |
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| 基金项目： | 国家攀登计划项目! (编号 85_41_0 2_0 6 ) |
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| 摘 要： | 将不同抗原含量的鸡新城疫和传染性法氏囊病油乳剂灭活疫苗分别免疫１７日龄雏鸡，测定了疫苗抗原含量与细胞免疫应答之间的关系。经Ｔ淋巴细胞转化试验结果表明，两种疫苗的抗原含量－细胞免疫应答曲线是一致的，随着抗原量的增加，活化的Ｔ淋巴细胞数量也相应增多，但是细胞免疫应答的可测时间是暂时的，于免疫７天达高峰，１７天后下降接近正常水平。
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| 关 键 词： | 鸡 新城疫 传染性法氏囊病 灭活疫苗 细胞免疫 |
| 修稿时间： | 2000-05-18 |
Effect of Antigen Amount of ND or IBD Inactivated Vaccines on Cell_Mediated Immune Response in Chickens |
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| HUANG Bing ,WANG Lili ,ZHANG Xiumei ,MU Jianqing ,AI Wu ,SONG Minxun ,CHEN Puyan. Effect of Antigen Amount of ND or IBD Inactivated Vaccines on Cell_Mediated Immune Response in Chickens[J]. Chinese Journal of Preventive Veterinary Medicine, 2000, 22(6): 433-435 |
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| Authors: | HUANG Bing WANG Lili ZHANG Xiumei MU Jianqing AI Wu SONG Minxun CHEN Puyan |
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| Affiliation: | HUANG Bing 1,WANG Lili 1,ZHANG Xiumei 1,MU Jianqing 1,AI Wu 1,SONG Minxun 1,CHEN Puyan 2 |
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| Abstract: | The relationships between antigen amount andcell_mediate immune response were determined using 17_day_age chickens vaccinated withdifferent dose of inactivated Newcastle disease(ND) oil adjuvant vaccines or infectiousbursal disease(IBD) oil adjuvant vaccines.The results showed that similar response curvesagainst IBD vaccine and ND vaccine were obtained by T lymphocyte transformation assay,andhigh content of vaccine antigen would activate more T lymphocytes in chickens.Inaddition,at day 7 post inoculation (PI) the stimulatory idies of T lymphocytes of allvaccinated chickens reached up to the top value,and descended near to normal level after17 days.It suggested that detectable time for the cell mediated immune response wastransient during the experiment. |
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| Keywords: | Newcastle Disease Infectious Bursal Disease Inactivated Vaccine Cell_Mediate lmmune |
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